The development of a miniature, disposable, wireless sensor for aqueous systems:
Based on a recently filed patent which covers a new measuring principle for on line monitoring of concentrations of many aqueous species, a new product is currently under development.

Development of a new analytical tool for monitoring of bioethanol production:
In innovative device was developed that allows for user friendly and fast screening of e.g. new yeast species for the production of (bio)ethanol. The systems allows for full control of six simultaneous yeast fermentations (see also Alcohol Fermentation Monitor).

Aqueous Electrolytes Solver:
An advanced simulation tool was developed that allows for performing complex equilibrium calculations on aqueous phase systems containing many (biological) components. Both a gas phase and solid formation are incorporated. The software was developed with a very user-friendly user interface. Specialist knowledge of numerical modeling, thermodynamics or setting up balance equations is not required (see also AESolve).

Development of a robotic camera system for use in Green Houses:
A web-based tool was developed that allows for taking high-resolution pictures of growing crops in greenhouses. The system comprises of a remotely controlled (both manual and automatic) robotic arm and a high-resolution camera. Pictures can be inspected on-line. Moreover, movies can automatically be generated, which provides insight in plant behavior that could otherwise no be detected. With image recognition software is it possible to obtain plant dimensions automatically.

Development of an on-line Ion Chromatograph for use in Greenhouses:
A fully automated on-line ion chromatograph was developed for the world leader of greenhouse automation product. The system is able to analyze all main ionic species present in drain water, which determine growth and well being of greenhouse vegetables and plants.

Development of a Dynamic Simulator for Simulated Moving Bed (SMB) Technology:
Chromatographic separation is one of the most important techniques for purification of biological components, such as enzymes, proteins, sugars, amino acids etc. Where chromatographic separation is intrinsically a batch process, SMB technology allows for continuous chromatographic separation. HaloteC developed a dynamic simulation model that can be used for dimensioning of SMB systems or operator training. It involves finding solutions to complex and large sets of partial differential equations.

Development of Wrapper Software for Metrohm Ion Chromatograph Analytical Software:
Wrapper and scheduler software was developed that allows users to take samples from several running fermentations and perform analyses of specific (organic) ions from the fermentation broth. Data is stored in a database and MS Excel reports are conveniently generated automatically.

Development of Innovative Pick and Transfer Software for a Biomek 2000 Robot:
For the world's largest manufacturer of industrial enzymes, new pick and transfer software was developed for the Biomek 2000 robot. The software allows for executing high throughput screening actions of potentially interesting new bacteria strains.

DCS Information Software with Performance Indicator Wizard:
For a large producer of fine chemicals, a data gathering system was developed which collects all factory information (as provided by a Yokogawa DCS system). These historic process data is subsequently made available via the company's local network. The system includes advanced visualization tools, export possibilities to MS Excel and a performance indicator wizard.

Invention of a Fermentative Capacity Meter:
A new analytical tool was developed and tested (TU Delft/ DSM) that allows for rapid screening of yeast quality. The apparatus involves an innovative measuring technique that requires only small amounts of a yeast suspension.

Development of a Molasses Quality Meter:
For a manufacturer of natural ethanol (bio-alcohol), a molasses quality screener was developed (hardware and software). The system is now operated as a standard in the company's quality lab. Results from this system are the basis for molasses feeding strategy of the industrial yeast fermentation.

Fermentation Information Centre:
Development of a tailor made large relational database structure for both industrial and R&D fermentation data, with a/o batch tracking features, MS Excel coupling, data mining capabilities and extensive graphical data representation.

Polysaccharide analysis and (Monte Carlo based) predictive model:
An FPLC-based analytical tool was developed on the basis of which a Monte Carlo simulation is automatically performed that determines the maximum allowable product storage time (on the basis of polysaccharide degradation).

MS-Excel based process simulator for fermentation processes:
HaloteC developed a conceptually new simulation tool for microbiologists and physiologists - hardly familiar with traditional simulation environments- to optimize industrial production processes based on their experimental data. In fact, large parts of the mathematical model are generated automatically, based on understandable user input on MS Excel sheets.

Dynamic model for describing dynamics of phage infections during batch fermentation:
A dynamic mathematical model was set-up for the largest manufacturer of natural lactic acid. A mechanistic model that describes phage infections was developed on the basis of literature data and many conversations with specialized microbiologists. The user interface was conveniently built in MS Excel.

Adaptive Control in Biotechnology:
In collaboration with two Universities of Technology and the main Dutch manufacturer of fermentation equipment, new approaches were developed with respect to software and equipment for easy process control of fermentation processes with better specifications than the current generation of (PID-) controllers.